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Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications."We're not saying that there's not a difference," says lead researcher Bruce G.
Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. Dosing: Oral: Children: 6-11 months: 1 mg once daily 12 months to 5 years: 1.25 mg once daily 6-11 years: 2.5 mg once daily Children /= 12 years and Adults: 5 mg once daily Supplied Syrup (Clarinex®): 0.5 mg/m L (480 m L) [bubble gum flavor] Tablet (Clarinex®): 5 mg Tablet, orally-disintegrating (Clarinex® Redi Tabs®): 5 mg [contains phenylalanine 1.75 mg/tablet] Adult (usual) Chronic idiopathic urticaria: 60 mg orally twice daily.
"The newer prescribed medications are very expensive, and until you try it, you don't really know whether an old-fashioned, 5- or 10-cent, first-generation capsule will take care of your symptoms without causing sedation." But others studies show a big difference -- including one trial conducted at the University of Iowa three years ago in which researchers gave patients simulated driving tests after administering either Allegra, Bendryl, a placebo, or enough alcohol to make the patient legally drunk.
"They found the people taking Allegra or placebo drove well.
"Today, most people would lead to nonsedating medications." And perhaps with good reason: Some 35 states in the U. have laws related to driving while impaired -- not only by alcohol, but also from antihistamines, says Cohen. "Zyrtec is a relatively non-sedating antihistamine, but it has a warning in the Physician's Desk Reference [which gives detailed information on prescribing drugs] about operating machinery when taking it," he tells Web MD.
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